بررسی اثرات هلیکوباکترپیلوری بر روی مالون دی آلدهید (MDA)، گلوتاتیون احیا (GSH)، گلوتاتیون اکسید (GSSG) و توتال آنتی اکسیدانت (TAC) در بیماران گاستریت مبتلا به عفونت هلیکوباکترپیلوری

    Background & Aims: Gastritis is an inflammation of the stomach, and has many possible causes. The major etiologic association of chronic gastritis is chronic infection by Helicobacter pylori (H.pylori) and that may act as a risk factor for proteins, lipids and DNA damages. The aim of this study was to investigate effects of Helicobacter Pylori infection on malondialdehyde, reduced glutathione, oxidized glutathione and total antioxidant capacity in patients with chronic gastritis.   Materials & Methods: In this study, Urease Test and PCR were performed on endoscopic gastric biopsy obtained from 150 persons. Sixty eight patients (males and females) aged between 30-50 years old with gastritis resulting from Helicobacter pylori was studied as patient group. Also 68 persons with other types of gastritis (Helicobacter pylori negative) were chosen as a control group.   Results: MDA ratio in patients with gastritis resulted by Helicobacter pylori was significantly increased compared to control group (p<0/05). The mean ± SE of GSH and TAC in patients w as decreased significantly (p<0/05). The analysis results show that the mean ± SE of GSSG in patients showed significant increase compared with control group .   Conclusion: These finding show that Helicobacter pylori infection can cause oxidative stress disorders that may act as risk factors for other diseases such as lipid metabolism disorders   SOURCE : URMIA MED J 2012: 23(1): 93 ISSN: 1027-3727